The human YB-1 protein plays multiple cellular roles, of which many are dictated by its binding to RNA and DNA through its Cold Shock Domain (CSD).Using molecular dynamics simulation approaches validated by experimental assays, Seasoning the YB1 CSD was found to interact with nucleic acids in a sequence-dependent manner and with a higher affinity f
Lung Jerseys volume reduction surgery (LVRS) is performed to the selected patients with lung emphysema who have higher residual volume, restricted pulmonary functions and limited diaphragmatic movement.Post-operative prolonged air leak is not uncommon following LVRS due to pulmonary emphysema.In some patients with prolonged air leak, pneumoderma ma
Abstract Background Successful deployment of clinical prediction models for clinical deterioration relates not only to predictive performance but to integration into the decision making process.Models may demonstrate good discrimination and calibration, but fail to match the needs of practising acute care clinicians who receive, interpret, and act
While the British electorate was asked to vote on a simple-sounding question during the UK referendum on EU membership in June 2016, the issues Kits at play were extremely complex.In order to help potential voters make sense of the debate, the authors ran a free Massive Open Online Course (MOOC) on the referendum in the weeks leading up to the vote
At present, most publish/subscribe middlewares suppose that there are equal Quality of Service (QoS) requirements for all users.However, in many real-world Internet of Things (IoT) service scenarios, different users may have different delay requirements.How to provide reliable differentiated services has become an urgent problem.The rise of Softwar